https://paraguay.bvsalud.org/base_bdnpar?q=&filter=indexed_database%3A%22BDNPAR%22+AND+publication_year%3A%222007%22 Sat, 13 Jun 2026 18:55:56 UTC https://paraguay.bvsalud.org/base_bdnpar/resource/?id=biblioref.referencesource.1018939 1018939 Tue, 24 Sep 2019 00:00:00 UTC https://paraguay.bvsalud.org/base_bdnpar/resource/?id=biblioref.referencesource.1018897 1018897 Tue, 24 Sep 2019 00:00:00 UTC https://paraguay.bvsalud.org/base_bdnpar/resource/?id=biblioref.referencesource.1018931 1018931 Tue, 24 Sep 2019 00:00:00 UTC https://paraguay.bvsalud.org/base_bdnpar/resource/?id=biblioref.referencesource.1018933 1018933 Tue, 24 Sep 2019 00:00:00 UTC https://paraguay.bvsalud.org/base_bdnpar/resource/?id=biblioref.referencesource.1018541 1018541 Tue, 24 Sep 2019 00:00:00 UTC https://paraguay.bvsalud.org/base_bdnpar/resource/?id=biblioref.referenceanalytic.306721
Dengue is an common epidemic disease in tropical and subtropical regions. Theelimination of breeding sites and vector control are among the most widely usedmeasures in the fight against the disease. Many strategies have been developed to keep low rates of mosquito populations. Several research studies have been focused on findingnatural products with insecticide and larvicide activity that could effectively control these mosquito populations without risks for the human populations and domestic animals. In this work, we have performed a series of bioassays with aqueous extracts of Paraguayan plants: Annona muricata (cherimoya), Bulnesia sarmentoi (palo santo), Melia azederach (paradise), Zanthoxylum chiloperone var. Angustifolium (tembetary hú) and Bixa orellana(uruku) in order to check the effectiveness and activity as larvicide of each plant gainst Aedes aegypti larvae. The larvae were collected in various areas of Asuncion and Great Asuncion during the yellow fever outbreak of 2007. The seeds of A. mucricata (cherimoya or custard apple) showed good larvicidal activity, i.e. at the minimum concentration of 5%, showed lethality against larvae comparable to that observed in positive controls(containing 1% temephos). On the other hand, M. azederach (paradise) and Z. chiloperone (tembetary hú) did not show any larvicidal activity at the same dose and even at higher doses. B. sarmientoi (palo santo) and Bixa orellana (uruku) showed somelarvicidal effect killing larva (18%) at 72 hours post-exposure. There was a marked difference in activity between the cherimoya seeds extract and the other extracts tested.]]> 306721 Tue, 22 Feb 2011 00:00:00 UTC https://paraguay.bvsalud.org/base_bdnpar/resource/?id=biblioref.referenceanalytic.306725
The current strategies recommended for the diagnosis of congenital Chagas disease require the conventional serological diagnosis in pregnant women to detect their infectionand the parasitological confirmation in the congenitally infected newborns. The detection of parasites in blood is not a method easy to apply at large scale and at public health level. Therefore, the conventional serology is recommended, i.e. detection of anti-T.cruzi IgG in infants older than eight months of age. Considering these recommendations, ourgroup has designed operative strategies in endemic rural areas that allow the rapid detection and treatment of congenitally infected infants. We have demonstrated that the decentralization of the serological studies from the Regional Hospitals contributes to thefast identification of the infected women together with the registration of their infection status in the family, prenatal and pediatric files. The results of over fifteen years of study of our group indicate that, in spite of the high sensitivity of PCR, its use with diagnosis purposes is very complex at large scale and in rural areas. However, the polymerase chain reaction (PCR) technique is very useful to evaluate the treatment of infected children The conventional IgG serology allows the unequivocal detection of congenitally infected infants after eight months of age (maximum time observed for the clearance of maternal antibodies). However, this strategy makes that the time required to rule out a congenital transmission in the follow-up diminishes adherence with an important loss of children that are not brought to control. The detection of congenital transmission casesincreases remarkably when a combination of the conventional serological techniques and an ELISA that we designed with the recombinant protein “shed acute phase antigen”(SAPA) is used, allowing the unequivocal detection of congenitally infected children at three months of age.]]> 306725 Tue, 22 Feb 2011 00:00:00 UTC https://paraguay.bvsalud.org/base_bdnpar/resource/?id=biblioref.referenceanalytic.306722
Illicit drug use and dependence is a serious social problem with high maternal and fetal morbidity. Supply increase and propitious social context allowed that the diffusion of theuse of illicit toxic substances entails a growing incidence in pregnant women who use illicit drugs and an increase of newborns affected by the practices of their mothers. Risk evaluation is difficult when gestation is exposed to illicit drugs because the results could be biased by the concomitant consumption of others toxic substances or by psychological and socio-sanitary unfavorable factors. Though a specific pattern of congenital anomalies has not been defined, in general it is considered that drug abuse has an increased risk ofanomalous outcomes in pregnancies. This risk is caused by an increase in the risk of congenital malformations due to the probable teratogenicity of some substances or the perinatal morbility affecting the fetal growth or normal pregnancy development. Although it has not been demonstrated effectively, there are also possible long-term repercussions in the learning capacity and behavior of the children exposed intra uterus. In conclusion, all pregnancies exposed to illicit drugs must be considered high risk pregnancies and measures should be taken so that the patients avoid these practices supported by a multidisciplinary team. Ideally, this team should start working before pregnancy implying the adoption of preventive measures such as information and public awareness of women in fertile age and support during pregnancy and maternal lactation.]]> 306722 Tue, 22 Feb 2011 00:00:00 UTC https://paraguay.bvsalud.org/base_bdnpar/resource/?id=biblioref.referenceanalytic.306726
The Department of Tropical Medicine of the Instituto de Investigaciones en Ciencias de la Salud has worked since the beginning (1982) in the research of Chagas disease performing serological studies, search of an animal model and control of Chagas disease via housing improvement. The department has an animal care facility, including primatesand mice, the latter used in the maintenance of Trypanosoma cruzi reference strains, as well as a colony of triatomine bugs. New research lines have been included such as thesearch of natural products with activity against T. cruzi and Leishmania sp. In the vectors area, studies about vectors ecology and distribution dynamics have been performed as well as field assays for the search of attractants efficient for the early detection of reinfestation. In 1995, parasites were isolated in the first human case of visceral leishmaniasis in Paraguay since 1903, starting then diagnosis studies of canine visceral leishmaniasis with other departments of the institute giving the alert about the urbanization of the disease in the Great Asunción. The department has a strain bank, unique in Paraguay, and maintains strains for the serological diagnosis of Chagas disease and leishmaniasis. It also offers clinical, serological, radiological and cardiologic care services for chagasic patients. The department continues working in these pathologies currently considered as neglected diseases, joining efforts with national and international institutions to identify leader compounds for the treatment, contribute to the knowledgeof these diseases and mainly answer to the commitment of providing assistance to the always relegated chagasic patient.]]> 306726 Tue, 22 Feb 2011 00:00:00 UTC https://paraguay.bvsalud.org/base_bdnpar/resource/?id=biblioref.referenceanalytic.306719
In Paraguay, dengue is an infection with a relatively recent circulation because it was first detected in the period 1988-89. The disease behaviour and circulation of the three serotypes (DEN 1, 2 and 3) between 2000 and 2006 show the high risk of epidemics andthe appearance of the hemorragic dengue. Our objective was to determine the prevalence of IgG and IgM antibodies against dengue virus in male and female adult subjects, fromurban and rural areas of Paraguay, which attended the IICS between February and April 2007. An observational, descriptive study was carried out including 605 patients and IgG and IgM antibodies were determined by using MAC ELISA and indirect ELISA respectively. Out of the 605 studied patients, 64% (388/605) was women and the population averageage was 31.9±13.5 years. Eigthy percent (482/605) came from urban areas and 13% (79/605) from rural areas. Out of the 605 subjects, 20% (121/605) were IgM positivebeing 55% (67/121) of them females. The IgG determination was made in 157 patients (by request), 61% (96/157) were negative and 39% (61/157) positive. According to the...]]> 306719 Tue, 22 Feb 2011 00:00:00 UTC